This article presented the concept of the sinister in the aesthetic work of the Spanish painter Francisco de Goya, who used his painting for a historical expressionism to capture the resistance and the Spanish impetus for independence from the French regime under the command of Napoleon Bonaparte. The analysis is based on a bibliographic and pictographic review on ductility of two categories: Goya and the representation of the sinister and the symbolic of painting in Iberian romanticism. It is intended to (...) demonstrate that, beyond a style, there exists in Goya art the hermeneutical supratextuality retained in the aesthetics of the sinister over the eternity of the canvas. From this reflection, it could be revealed that the aesthetic of the sinister mediated by the sublime becomes an expression that causes fascination, curiosity and at the same time rejection. Hence, when speaking of the sinister, we refer to that which is veiled and which needs to cast off its shadow, in order to be able to see itself clearly. In Goya, the tragic is connected: the faces full of drama reveal the disturbing reality of their surroundings and his work leaves encoded images of emotions, history and horror sealed in the murals of his room. It is at that moment that the sublime fulfills the fundamental role of being the bridge that allows access to knowledge in the face of the questions that are part of existence, since in the philosophical amazement it is sought to reveal the doubtful, hidden and disturbing that is part of our humanity. (shrink)

El objetivo del presente documento es analizar las ideas de espacio y tiempo en Hume y mostrar la peculiaridad de dichas ideas, puesto que no provienen de la experiencia y, por el contrario, son necesarias para ella. Para ello analizaré los argumentos que presentó Hume al abordar dichas ideas, con el fin de iluminar y proporcionar una comprensión diferente a la tradicional lectura que se hace de las nociones de espacio y tiempo de Hume, la cual está inmersa por la (...) postura newtoniana del espacio y el tiempo. Sin embargo, esta tarea no se puede realizar de manera aislada a las investigaciones de su tiempo sobre estas nociones, ni tampoco aislarla del sistema del que hace parte, es decir el sistema epistemológico humeano. Así, el primer paso será abordar a grandes rasgos las principales posturas de la época sobre este tema y, en segundo lugar, abordaré el problema en torno a las ideas de espacio y tiempo en Hume, que dividiré en dos partes: la lectura fuerte que se hace sobre estos temas; es decir, la lectura tradicional y la lectura débil que es la que propone Kemp Smith y es sobre la que sustentaré mi tesis: las ideas de espacio y tiempo en Hume son a priori. (shrink)

This article has as main objective, to present the problems on Hume’s version about believes and its interpretation. This has been of great importance not only on Humean philosophy, but also in the subsequent philosophical thinking due to the fact that his proposal is about the impossibility of reasoning on the matters of facts. Hence, the belief would supply the emptiness of reasoning, and it would fundament and be the motor of our actions in the absence of reasoning. The main (...) objective is to show belief not as a lived idea, as Hume presents it, but as a propositional attitude that moves us towards action. Therefore, belief can be understood as two different but closely related ways: as a propositional fact (we accept what we believe as true) and as a disposition to act. (shrink)

Este artículo se propone dar cuenta de los posicionamientos, caracterizaciones y normatividades que los periodistas argentinos ensayaron y pusieron a prueba en el espacio público a propósito de la controversia sobre el compromiso político en el periodismo. Retomando los trabajos que dieron lugar a la perspectiva sociológica francesa (Latour, Boltanski y Lemieux), buscará dar cuenta de los elementos nodales de la controversia y las formas de resolver los argumentos en las situaciones y contextos de su emergencia. El despliegue de la (...) controversia pondrá de manifiesto, finalmente, los marcos valorativos que les permiten a los periodistas actuar de acuerdo a la lógica de la actividad y a su sentido de justicia. (shrink)

Resumen El objetivo principal del artículo es ahondar en la experiencia de la tortura desde una postura fenomenológica con la finalidad de dilucidar las diferencias entre las posibles representaciones de la muerte que una persona puede experimentar y la vivencia de la tortura. De acuerdo con esta investigación, primero explicaré en qué sentido se tomará el fenómeno de la muerte, dando paso a la relación que el dolor y la tortura mantienen, para mostrar que la terrible naturaleza de esta actividad (...) no se encuentra ligada al violento proceso afectivo desencadenado mediante el dolor, sino a la impotencia que el ser humano siente al saberse torturado por otro. De esta forma, se rompe cualquier nexo que el torturado pueda tener con el mundo. La tortura no genera una experiencia realmente dada de la muerte, pero sí proporciona al sujeto trascendental la vivencia más cercana que podría tener de su propia muerte.The main objective in the article is to delve in the experience of torture from a phenomenological stance to elucidate the differences between the possible representations of death that a person can experience and the experience of torture. According to this investigation, first I explain in what sense the phenomenon of death will be understood, to give way to the relation that pain and torture have. In order to show that the terrible nature of torture it is not bound to the affective violent process that is triggered by pain, rather to the helplessness that the human being feels when it knows that he is being tortured by the other. In this way, the tortured breaks any nexus that it may have with the world. Torture does not generate a truly given experience of death, but it does provide the transcendental subject with the closest experience that he may have of his own death. (shrink)

Este artículo estudia los mecanismos de circulación de intelectuales hispanoamericanos en Colombia durante la segunda mitad del siglo xix. Dicho período evidenció una modernización de la prensa y el mercado del libro en la región, que expandió el espacio de acción de los intelectuales, generando conexiones entre ellos y permitiendo el desarrollo de un debate continental, especialmente alrededor del liberalismo. En particular, el liberalismo colombiano tuvo álgidos debates con el liberalismo chileno. A raíz de los intercambios, se consolidó una comunidad (...) intelectual hispanoamericana. (shrink)

La exploración sobre la naturaleza, el significado y la estructura del concepto de crisis, y la definición misma de una crisis social convocan, primero, al uso, por lo general, ambiguo del término y, segundo, a las condiciones que manifiesta el mundo contemporáneo. Así, en este libro se procura analizar el, popularmente empleado pero poco esclarecido, concepto de crisis, sobre todo, en dos autores de la segunda generación de la teoría crítica, Habermas y Offe. La intención fundamental del texto es crear, (...) a partir de estos autores, un enfoque para estudiar las dinámicas patológicas de las sociedades contemporáneas. (shrink)

RESUMEN En el marco de la pregunta por la actualidad del pensamiento político de Hegel ha surgido en las últimas décadas una renovada vertiente interpretativa que defiende la tesis de la indeterminación del monarca como un elemento necesario en los Principios de la filosofía del derecho. Esta tesis consiste, por un lado, en que el monarca, aun como soberano, cumple una función meramente protocolar dentro de la Constitución; y por otro lado, afirma que, en esa medida, su particularidad o su (...) carácter personal es completamente irrelevante para la administración y desarrollo de los asuntos públicos. Sin embargo, a partir de una revisión detallada de los argumentos originales de la obra se logra apreciar que dicha tesis resulta problemática. Este trabajo se propone explicitar las razones que demuestran dicha inconsistencia, así como señalar otros aspectos particulares en la argumentación hegeliana que invitan a poner nuevamente la mirada en este elemento complejo de su obra y pensamiento. ABSTRACT Within the framework of the question about the actuality of Hegel's political thought, a renewed interpretative perspective has arisen in recent decades, which defends the thesis of the monarch's indetermination as a necessary component at Elements of Philosophy of Right. This thesis claims, on the one hand, that the monarch, even as a sovereign, fulfills a titular function within the Constitution; and on the other hand, it maintains that, to that extent, his particularity or personal character is completely irrelevant for the determination of public affairs. However, based on a detailed review of the original arguments of Hegel's work, it is possible to appreciate that this thesis is problematic. This article seeks to explain the reasons which prove this inconsistency. It also highlights other particular aspects of Hegel's argument which invite to reconsider this complex aspect of his work and thought. (shrink)

Since it implies a reduction in the quality and the quantity of the natural resources, environmental degradation is a present day problem that requires immediate solutions. This situation is driving firms to undertake an environmental transformation process with the purpose of reducing the negative externalities that come from their economic activities. Within this context, environmental marketing is an emerging business philosophy by which organizations can address sustainability issues. Moreover, environmental marketing and orientation are seen as valuable strategies to improve a (...) firm's competitiveness. However, the literature that has analyzed the link between environmental strategies and firms' results has been inconclusive and contradictory. In this study, we propose and test a model that analyses how the implementation of ecological issues within a firm's marketing strategy and orientation influences organizational results. Data were obtained through a survey sent to Spanish manufacturing firms. The results show that environmental marketing positively affects firms' operational and commercial performance and this improvement will influence their economic results. Moreover, environmental marketing is revealed as an excellent strategy to obtain competitive advantages in costs and in product differentiation. Thus, this study agrees with the researchers who affirm that environmental strategies positively affect firm's competitiveness while reducing environmental impact. (shrink)

Since it implies a reduction in the quality and the quantity of the natural resources, environmental degradation is a present day problem that requires immediate solutions. This situation is driving firms to undertake an environmental transformation process with the purpose of reducing the negative externalities that come from their economic activities. Within this context, environmental marketing is an emerging business philosophy by which organizations can address sustainability issues. Moreover, environmental marketing and orientation are seen as valuable strategies to improve a (...) firm's competitiveness. However, the literature that has analyzed the link between environmental strategies and firms' results has been inconclusive and contradictory. In this study, we propose and test a model that analyses how the implementation of ecological issues within a firm's marketing strategy and orientation influences organizational results. Data were obtained through a survey sent to Spanish manufacturing firms. The results show that environmental marketing positively affects firms' operational and commercial performance and this improvement will influence their economic results. Moreover, environmental marketing is revealed as an excellent strategy to obtain competitive advantages in costs and in product differentiation. Thus, this study agrees with the researchers who affirm that environmental strategies positively affect firm's competitiveness while reducing environmental impact. (shrink)

Entre los muchos aspectos por los cuales se conoce la filosofía de Hegel, la caracterización y defensa que este realiza de una monarquía constitucional hereditaria en sus _Principios de la Filosofía del Derecho_, ha sido, sin duda alguna, uno de los temas más discutidos. En consideración del amplio conflicto entre posturas, enfoques e interpretaciones de diversa índole, así como de la dificultad que encarnan muchas de las afirmaciones de Hegel al respecto, puede afirmarse que el problema sobre el verdadero sentido (...) o el significado de la monarquía en su filosofía continúa en muchos aspectos aún sin resolverse. El propósito de este escrito no consiste en hacer una reconstrucción de las más importantes interpretaciones, sino, más bien, en identificar cuáles son las perspectivas o modelos de análisis más importantes que han estado a su base. Ello, con el fin de contrastarlas directamente con las propias advertencias metodológicas de Hegel en su obra y justificar, a partir de allí, la necesidad de priorizar y dar un mayor desarrollo a una perspectiva y forma específica de abordar el problema. Al final, se ofrecerán algunas consideraciones y sugerencias metodológicas para la realización de un análisis tal, que pudieran ayudar a encontrar nuevas respuestas o elementos de interpretación al respecto. (shrink)

Over the last decade the modeling and the storage of biological data has been a topic of wide interest for scientists dealing with biological and biomedical research. Currently most data is still stored in text files which leads to data redundancies and file chaos.In this paper we show how to use relational modeling techniques and relational database technology for modeling and storing biological sequence data, i.e. for data maintained in collections like EMBL or SWISS-PROT to better serve the needs for (...) these application domains.For this reason we propose a two step approach. First, we model the structure (and therefore the meaning of the) data using an Entity-Relationship approach. The ER model leads to a clean design of a relational database schema for storing and retrieving the DNA and protein data extracted from various sources. Our approach provides the clean basis for building complex biological applications that are more amenable to changes and software ports than their file-base counterparts. (shrink)

Introduction:Episodic memory is a cognitive process that allows the recall of experiences, learning, and the pursuit of future goals. During the aging process, episodic memory declines negatively, impacting social and psychological aspects in the elderly. Such intervention strategies as cognitive training are non-pharmacological ways of reducing these losses.ObjectiveWe systematically reviewed studies of the cognitive training of episodic memory in healthy elderly individuals and elderly individuals with clinical conditions.MethodWe systematically searched the PubMed, PsycNET, Web of Science, and SciELO databases using the (...) descriptors “Episodic Memory” AND “Training” AND “Elderly” OR “Aging” OR “Dementia” in English and translated into Portuguese.ResultsOf the 572 articles that were identified by the search, 23 were included in the final analysis. The main variables that comprised the intervention protocols were investigated, as well as the outcome variables, efficacy, and risk of bias. The main results indicated effectiveness with regard to different forms of the cognitive training of episodic memory.ConclusionEpisodic memory training among the elderly can mitigate the negative effects of cognitive decline in dementia and healthy subjects promoting impacts at social, psychological, and economic levels. Although it is a widely studied topic, further empirical studies on the utility of episodic memory training in healthy elderly individuals and elderly individuals with clinical conditions are still needed. (shrink)

Child mortality (the mortality of children less than five years old) declined considerably in the developing world in the 1990s, but infant mortality declined less. The reductions in neonatal mortality were not impressive and, as a consequence, there is an increasing percentage of infant deaths in the neonatal period. Any further reduction in child mortality, therefore, requires an understanding of the determinants of neonatal mortality. 209,628 birth and 2581 neonatal death records for the 1998 birth cohort from the city of (...) São Paulo, Brazil, were probabilistically matched. Data were from SINASC and SIM, Information Systems on Live Births and Deaths of Brazil. Logistic regression was used to find the association between neonatal mortality and the following risk factors: birth weight, gestational age, Apgar scores at 1 and 5 minutes, delivery mode, plurality, sex, maternal education, maternal age, number of prior losses, prenatal care, race, parity and community development. Infants of older mothers were less likely to die in the neonatal period. Caesarean delivery was not found to be associated with neonatal mortality. Low birth weight, pre-term birth and low Apgar scores were associated with neonatal death. Having a mother who lives in the highest developed community decreased the odds of neonatal death, suggesting that factors not measured in this study are behind such association. This result may also indicate that other factors over and above biological and more proximate factors could affect neonatal death. (shrink)

Plagiarism is a serious, yet widespread type of research misconduct, and is often neglected in developing countries. Despite its far-reaching implications, plagiarism is poorly acknowledged and discussed in the academic setting, and insufficient evidence exists in Latin America and developing countries to inform the development of preventive strategies. In this context, we present a longitudinal case study of seven instances of plagiarism and cheating arising in four consecutive classes of an Epidemiology Masters program in Lima, Peru, and describes the implementation (...) and outcomes of a multifaceted, “zero-tolerance” policy aimed at introducing research integrity. Two cases involved cheating in graded assignments, and five cases correspond to plagiarism in the thesis protocol. Cases revealed poor awareness of high tolerance to plagiarism, poor academic performance, and widespread writing deficiencies, compensated with patchwriting and copy-pasting. Depending on the events’ severity, penalties included course failure and separation from the program. Students at fault did not engage in further plagiarism. Between 2011 and 2013, the Masters program sequentially introduced a preventive policy consisting of: intensified research integrity and scientific writing education, a stepwise, cumulative writing process; honor codes; active search for plagiarism in all academic products; and a “zero-tolerance” policy in response to documented cases. No cases were detected in 2014. In conclusion, plagiarism seems to be widespread in resource-limited settings and a greater response with educational and zero-tolerance components is needed to prevent it. (shrink)

Over the last decade the modeling and the storage of biological data has been a topic of wide interest for scientists dealing with biological and biomedical research. Currently most data is still stored in text files which leads to data redundancies and file chaos.In this paper we show how to use relational modeling techniques and relational database technology for modeling and storing biological sequence data, i.e. for data maintained in collections like EMBL or SWISS-PROT to better serve the needs for (...) these application domains. (shrink)

A partir de un estudio longitudinal sobre cultura política en chilenos, discutimos la paradojal evidencia encontrada en la literatura que plantea que, por un lado, las actitudes políticas más pro-democráticas y anti-autoritarias se observarían en sectores sociales acomodados y, por otro lado, las actitudes más pro-conservadoras y anti-igualitaristas se observarían en grupos sociales dominantes. Nuestros datos muestran que el patrón de actitudes políticas (autoritarismo, apoyo a la democracia, conservadurismo y nacionalismo) es similar entre personas de derecha de estrato alto, izquierda (...) de estrato bajo, y centro de estrato medio. En cambio, quienes manifiestan una orientación política incongruente con su condición socioeconómica presentan actitudes políticas diferenciadas del patrón predominante. Concluimos que la paradoja puede resolverse explicando el patrón de actitudes políticas de un grupo en función del (des)ajuste de la orientación política a sus condiciones socioeconómicas. (shrink)

Diversität ist eines der zentralen Themen unserer Zeit. Sie durchdringt alle Lebensbereiche unserer Gesellschaften. Das Nachdenken über Diversität reicht von den Naturwissenschaften über die Geschichtswissenschaften, die Gesellschaftswissenschaften, die Philosophie bis zu den Künsten. Diversität ist zudem politisch und emotional beladen. Man denke an gesellschaftliche Minderheiten und ihre Rechte oder an das massive Artensterben unserer Tage. In diesem Buch wird nicht nur über Einzelaspekte von Diversität berichtet, es wird auch eine Synthese versucht. Drei einleitende Kapitel der HerausgeberInnen führen verständlich in komplexe (...) interdisziplinäre Problemzusammenhänge ein. Der Band versammelt 17 Beiträge namhafter Autorinnen und Autoren aus den Bereichen Kunst-, Kultur- und Wissenschaftsgeschichte, Medizin und Gesellschaftstheorie.00. (shrink)

Forschungen zur verkörperten Intelligenz und zu den symbolischen Vermittlungen des menschlichen Geistes werden bislang zumeist in getrennten Disziplinen betrieben. Die aus der Kulturphilosophie, Kunst- und Bildwissenschaft, Theologie, Medizin, Psychiatrie, Psychologie und Kognitionswissenschaft stammenden Beiträge des Bandes vereint jedoch das gemeinsame Ziel, einen umfassenden Begriff von Verkörperung zu entwickeln, der die Grenzziehung zwischen kulturalistischen und naturalistischen Ansätzen überwindet.

La literatura sobre razonamiento probatorio busca incidir en la determinación de los hechos en los procesos judiciales. Para alcanzar dicho propósito, no basta con dirigir la mirada hacia disciplinas extrajurídicas exitosas e integrar lo que de ellas pueda extraerse a las teorías jurídicas de la prueba y a la práctica judicial. Es necesario, además, considerar el tipo de hechos a probar, los roles de las reglas jurídicas aplicables, y asumir que litigantes y jueces, actuando en un contexto institucional, podrán ser (...) más o menos agudos en la discusión fáctica, entre otras cosas. Minimizar la influencia de tales factores expone a los estudios probatorios a tener un bajo rendimiento práctico. Algo de esto ha ocurrido con la llamada concepción racionalista de la prueba. Su innegable aporte al debate académico en español no ha ido a la par de su impacto judicial. Para explicar esta brecha entre teoría y práctica, identificamos tres creencias-obstáculo que afectan a su discurso sobre la prueba y que deben ser sorteadas si lo que se busca es influir en la forma en que se juzgan los hechos en un sistema judicial realmente existente. (shrink)

Se realizan algunas conceptualizaciones que constituyen premisas de la Universidad del siglo XXI, como es el desarrollo endógeno, como una mirada de la institución de educación superior para lograr la transformación y desarrollo local sustentable. La realidad impone, que el proceso formativo, no sea solo hacia dentro sino que los actores internos y externos confluyan en los propósitos de progreso económico y social y la Universidad se convierta en el líder que guía dicho desarrollo. Some conceptualizations that constitute premises of (...) the University of the XXI Century, like the endogenous development as a look of the high education institution to achieve the transformation and local sustainable development, were made. The reality imposes that the formative process is not only projected to the inside but that the internal and external actors concur in the intention of getting a social and economic progress and that the university becomes the leader that guides this development. (shrink)

The assembly of products or components by operators in industries is a complex task with recurring problems. In these processes, operators often make errors that can lead to defective products. Therefore, they need to be inspected later to verify their correct assembly. The main problems are caused by several reasons including high employee turnover, lack of experience in manufacturing specific products or confusion in interpreting instructions to assemble similar components. In this paper, a novel structured language aimed to describe the (...) required actions to manufacture a product in industrial assembly environments is presented. The main contribution is to provide a formal language to feed automatic systems that can verify through visual control whether the actions performed by the operator are carried out following the standard described by this language. In general, the use of this formal language will allow to minimize the negative impact of errors during assembly and to reduce waste in many forms in the industry. (shrink)

Meeting 5G high bandwidth rates, ultra-low latencies, and high reliabilities requires of network infrastructures that automatically increase/decrease the resources based on their customers’ demand. An autonomous and dynamic management of a 5G network infrastructure represents a challenge, as any solution must account for the radio access network, data plane traffic, wavelength allocation, network slicing, and network functions’ orchestration. Furthermore, federation among administrative domains (ADs) must be considered in the network management. Given the increased dynamicity of 5G networks, artificial intelligence/machine learning (...) (AI/ML) solutions are strong candidates able to learn, and take quick provisioning decisions upon fast changes in network conditions. Therefore, this chapter presents an analysis of the state-of-the-art solutions for 5G networks’ management, where AI/ML solutions are discussed and compared with traditional methods. Additionally, the chapter provides a technology overview of both standards, and existing solutions regarding the 5G network management, and directions toward the integration of AI/ML in 5G networks. (shrink)

As clinical trials end, little is understood about how participants exiting from clinical trials approach decisions related to the removal or post-trial use of investigational brain implants, such as deep brain stimulation (DBS) devices. This empirical bioethics study examines how research participants experience the process of exit from research at the end of clinical trials of implanted neural devices. Using a modified grounded theory study design, we conducted semi-structured, in-depth interviews with 16 former research participants from clinical trials of DBS (...) and responsive neurostimulation (RNS). Open-ended questions elicited motivations for joining the trial, understanding of study procedures at the time of initial informed consent, the process of exiting from research, and decisions about device removal or post-trial device use. Thematic analysis identified categories related to: limited preparedness for the end of research participation, straightforwardness of decisions to explant or keep the device, reconciling with the end of research participation, reconciling post-trial expectations, and achieving a sense of closure after exit from research. A preliminary theoretical model describes contextual factors influencing the process and experience of exit from research. Experiences of clinical trial participants should guide research practices to enhance the ethical design and conduct of clinical trials in DBS and other brain devices. (shrink)

Objective: To examine changes in patients’ desired control of the deep brain stimulator and perception of global life control throughout DBS.Methods: A consecutive cohort of 52 patients with Parkinson’s disease was recruited to participate in a prospective longitudinal study over three assessment points. Semi-structured interviews assessing participants’ desire for stimulation control and perception of global control were conducted at all three points. Qualitative data were coded using content analysis. Visual analog scales were embedded in the interviews to quantify participants’ perceptions (...) of control over time.Results: Participants reported significant increases in their perception of global control over time and significant declines in their desired control of the stimulation. These changes were unrelated to improvements in motor symptoms. Improvements in global control were negatively correlated with a decline in desired stimulation control. Qualitative data indicate that participants have changed, nuanced levels of desired control over their stimulators. Increased global life control following DBS may be attributed to increased control over PD symptoms, increased ability to engage in valued activities, and increased overall self-regulation, while other domains related to global control remained unaffected by DBS.Conclusions: There are few empirical data documenting patients’ desire for stimulation control throughout neuromodulation and how stimulation control is related to other aspects of control despite the growing application of neuromodulation devices to treat a variety of disorders. Our data highlight distinctions in different types of control and have implications for the development of patient-controlled neurostimulation devices. (shrink)

Después de la publicación de su tesis doctoral titulada La acción (1893), el filósofo francés Maurice Blondel escribió algunas obras en las que trató asuntos de enorme importancia, tanto en el campo filosófico como teológico, que desarrollaron las temáticas centrales de La acción, obra que a finales del siglo XIX generó tanto revuelo en el ambiente filosófico francés. Con la conciencia de su actualidad y su inmenso valor para una perspectiva novedosa de la metafísica y el diálogo fe-razón, se pretende (...) aquí una aproximación a cuatro obras que los estudiosos del pensamiento blondeliano han llamado “menores”. El presente artículo desarrolla los principales aportes de dichas obras a la reflexión filosófica contemporánea, indagando al mismo tiempo por la filosofía de la acción en cada una de ellas. Después de una corta biografía del pensador en cuestión, se abordará el significado de la filosofía de la acción con vistas a su elucidación para el lector. Posteriormente se presentará el contexto histórico de cada obra y se mostrarán sus vínculos con La acción, para terminar con algunas reflexiones que su lectura suscita en nuestro tiempo, cuyos desafíos son similares a los que Blondel tuvo que enfrentar en su momento. (shrink)

In this study I focus on the importance of the concept of the apocryphal to understand the work of Antonio Machado in its entirety. The concept of the apocryphal implies a critical position before tradition: the negation-forgetting of the real past, the affirmation reinvention of a possible past. The apocryphal comes to solve, according to Machado, the great crises that modern poetry faced: the loss of the ties that bound humankind and the universe, the relationship between high culture (...) and mass culture, the relationship between the ethical and the aesthetic in the work of art. (shrink)

Deep brain stimulation is a well-established therapy for the motor symptoms of Parkinson’s disease, but there remains an opportunity to improve symptom relief. The temporal pattern of stimulation is a new parameter to consider in DBS therapy, and we compared the effectiveness of Temporally Optimized Patterned Stimulation to standard DBS at reducing the motor symptoms of PD. Twenty-six subjects with DBS for PD received three different patterns of stimulation while on medication and using stimulation parameters optimized for standard DBS. Side (...) effects and motor symptoms were assessed after 30 min of stimulation with each pattern. Subjects experienced similar types of side effects with TOPS and standard DBS, and TOPS were well-tolerated by a majority of the subjects. On average, the most effective TOPS was as effective as standard DBS at reducing the motor symptoms of PD. In some subjects a TOPS pattern was the most effective pattern. Finally, the TOPS pattern with low average frequency was found to be as effective or more effective in about half the subjects while substantially reducing estimated stimulation energy use. TOPS DBS may provide a new programing option to improve DBS therapy for PD by improving symptom reduction and/or increasing energy efficiency. Optimizing stimulation parameters specifically for TOPS DBS may demonstrate further clinical benefit of TOPS DBS in treating the motor symptoms of Parkinson’s disease. (shrink)